Fluoroquinolones- and Collagen-Associated Severe Toxicity

Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study

OBJECTIVES Fluoroquinolone-associated tendon ruptures are a recognised complication, but other severe collagen-associated adverse events may also be possible. Our objectives were to confirm the association of fluoroquinolones and tendon rupture, to clarify the potential association of fluoroquinolones and retinal detachment, and to test for a potentially lethal association between fluoroquinolo...

Achilles tendinitis associated with fluoroquinolones.

AIMS To determine whether there is an association between use of fluoroquinolones and tendinitis in a large population under everyday circumstances. METHODS A retrospective cohort study was carried out in a dynamic population. Data came from the IPCI-database which consists of all data on consultations, morbidity, prescriptions and other interventions, as registered by GPs in a source populat...

Peripheral neuropathy associated with fluoroquinolones.

OBJECTIVE To survey cases of fluoroquinolone-associated adverse events that included peripheral nervous system (PNS) symptoms posted on Internet Web sites. METHODS Cases were obtained with the assistance of members of Web sites formed by people sustaining fluoroquinolone-related events. Information obtained met the standards of MedWatch, and each reported case was assessed using the Naranjo p...

Peripheral neuropathy associated with fluoroquinolones.

Esophagitis dissecans superficialis associated with severe clindamycin toxicity.

A 42-year-old woman with type 1 diabetes mellitus and a regular smoking habit (19 pack-years) presented with dysphagia, nausea and vomiting over the previous week, a er clindamycin treatment for infected diabetic foot ulcers. An esophagogastroduodenoscopy revealed sloughing reddish membranes in the distal esophagus, adjacent to intact healthy mucosa that were easily removed (Figs.1, 2). Histopa...